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In our study, co-occurrence network analysis revealed a significant increase in the gut microbiota Bacteroides barnesiae in ESC group, which was strongly positively correlated with key sphingolipid metabolism-related metabolites (such as Sphingosine and Sphingosine-1-phosphate) in the serum, as well as with Sptlc1, a protein associated with sphingolipid metabolism in the hippocampus
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Collectively, these findings highlight autophagy as a key mechanism by which NAD + exerts hepatoprotective effects, thereby linking upstream metabolic imbalance to downstream pathological outcomes
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